![]() Next we give notions of cell state, determined by its epigenetic array, and cell event, which is a change of cell state, and formalize development as a graph (tree) of cell states connected by 5 types of cell events, corresponding to the processes of cell division, cell growth, cell death, cell movement and cell differentiation. Second, we suggest a set of rules for converting this epigenetic information into instructive signals for cell event for each cell, as well as for transforming it after each cell event. ![]() First, we consider a possibility that the evolution of shape is determined by epigenetic information, responsible for realization of different types of cell events. We have recently proposed a set of concepts, aiming to respond to these questions and to provide an appropriate mathematical formalization of the geometry of morphogenesis. ![]() A fundamental theoretical question is where exactly do these instructions for (re-)construction reside and how are they implemented? This process encompasses numerous biological processes ranging from embryogenesis to regeneration following crisis such as amputation or transplantation. The process of morphogenesis is an evolution of shape of an organism together with the differentiation of its parts.
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